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UID:6a68b8fd2d05e@www.leap-up.com
DTSTAMP:20260728T161317Z
DTSTART:20261015T100000
DTEND:20261015T110000
SUMMARY:Webinar: Current Progress in Vaccine Development Against Klebsiella pneumoniae From Antigen Discovery to Clinical Translation
DESCRIPTION:Klebsiella pneumoniae poses a growing global threat due to rising multidrug resistance and hypervirulence. This talk reviews current vaccine approaches—including glycoconjugates\, protein antigens\, and OMVs—alongside key translation challenges like antigenic diversity and preclinical models.\nHighlights of the presentation\n\nThe clinical and public-health importance of multidrug-resistant and hypervirulent K. pneumoniae.\nCurrent understanding of protective immunity against colonisation\, invasive infection\, pneumonia\, and sepsis.\nCapsular polysaccharides and lipopolysaccharide O antigens as vaccine targets.\nProgress in glycoconjugate\, recombinant protein\, outer-membrane-vesicle\, and multivalent vaccine platforms.\nUse of reverse vaccinology\, structural biology\, and computational antigen-selection approaches.\nChallenges created by capsular and serotypic diversity.\nSelection of clinically relevant animal models\, endpoints\, and target populations.\nKey scientific and translational requirements for advancing candidates towards clinical development.\nFuture opportunities for integrating vaccination with antimicrobial-resistance control strategies.\n
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