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The evidence is based on a misfolding of the protein alpha-synuclein, which leads to harmful deposits in the brain during the course of the disease. The study, published in the journal EMBO Molecular Medicine, is based on cerebrospinal fluid samples from two independent patient cohorts and was carried out using a patented, infrared-based sensor technology that was originally developed for the early detection of Alzheimer's disease. The so-called iRS platform has now been successfully transferred to Parkinson's disease. It recognises early molecular changes long before clinical symptoms such as movement disorders occur. This is of particular importance, as Parkinson's disease is usually only diagnosed in the late stages, when irreversible damage has already occurred in the brain. The new biomarker not only opens up diagnostic possibilities, but can also help to track the course of the disease and assess the effectiveness of new therapies in studies. It could therefore also play a key role in the development of future drugs.
Press release by "idw - Informationsdienst Wissenschaft" from 25 April 2025
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