Robots in use for research and diagnostics

Compared to the previous 15 tests, the new system could carry out more than 1,000 tests for neutralising antibodies every day. As this means that significantly more people can be tested for their immunity to the various strains of coronavirus, automation can also help UTMB researchers gain a better understanding of the effectiveness of COVID vaccines.

The continuous mutation of the coronavirus since its first appearance at the end of 2019 poses major challenges for both researchers and governments. They must constantly find ways to control and limit its spread. Although numerous vaccines have been developed, the rapid mutation of the virus makes it difficult to find the most effective protection against each variant.

„The ability to perform an increased number of tests on a daily basis is the key to obtaining more data on individual immunity profiles. This will help control the spread of the virus," said Dr Michael Laposata, professor and chair of the Department of Pathology at UTMB. The automated system that we have developed together with ABB enables us to achieve our goals precisely, flexibly and safely. This is because we can carry out the tests more quickly and do not have to expose our laboratory staff to any potential risk of infection, as is the case with manual testing.

The aim of the automated test system is to specifically detect a neutralising SARS-CoV-2 antibody without cross-reacting with another infection, which may make this test the gold standard for COVID-19 serological testing. The resulting data can then be used both by the people tested and by researchers to better understand immunity due to vaccination or infection. In addition, the data can also serve as a basis for local political decision-makers to minimise the risk of further infections, for example by avoiding virus hotspots.

„This project is a clear example of how robotics can increase speed and efficiency while making work safer for the researchers involved,

says Daniel Navarro, Head of Consumer Segments and Service Robotics at ABB. „Working closely with UTMB, we are pooling our expertise in biology, laboratory processes, automation and software to launch an automated robotic solution that will significantly advance our efforts to combat the COVID pandemic.“

From development
The automated test system for neutralising antibodies was programmed using the offline programming software „RobotStudio®“ to simulate and test different combinations of laboratory devices and robot positions in order to develop the most effective concept. The result: a functioning system that could be put into operation within 18 months. „What we have achieved in this project in such a short time is extraordinary“, says Juan Garcia, Director Laboratory Services at UTMB. Dr Michael Laposata adds: "None of what we have achieved would have been possible without ABB and the other project participants. From the creation and simulation of a working concept in the RobotStudio® software to the commissioning of the automated test cells that are now in use in our laboratory – this is the best teamwork I have experienced in 35 years in this profession.“

Another advantage of the automated system is that it can also be used for other types of virus tests. This project is just one of several around the world where ABB robots are being used to find ways to protect against COVID.

Article by LABO from 06.02.2023