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Award and publication on genetic code expansion
Prof Dr Irene Coin from Leipzig University, together with Prof Dr Thomas Sakmar (Rockefeller University), has published a comprehensive paper on genetic code extension (GCE) in the renowned journal Chemical Reviews. This technology makes it possible to modify proteins with artificial building blocks directly in living cells and thus gain new insights into the structure and function of membrane proteins.
11/11/2024
The publication, which is based on around 450 citations, provides researchers from other disciplines in particular with a structured overview of the development and application of GCE technology. For its contributions to biochemical research, Coin's laboratory was honoured with the „Blue Flame Award“ from the Addgene organisation. The award honours a plasmid developed by Dr Robert Serfling, which has been disseminated more than a hundred times worldwide. Plasmids are central tools in genetic research and enable the exchange of genetic material.
Prof. Coin's work makes an important contribution to research at Leipzig University, particularly in the Collaborative Research Centre 1423 on the dynamics of GPCR activation. GCE technology opens up new possibilities for the development of innovative therapeutics and the understanding of natural proteins.
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