Bone implants: Biomaterial helps with bone replacement
A team from the Trauma Surgery Clinic at Hannover Medical School under the direction of Prof Dr Philipp Mommsen had to reconstruct the segmental bone defect on the shaft of the radius following an open, infected third-degree fracture as a result of a traumatic gunshot wound.
Prior to treatment at Hannover Medical School, the Ukrainian soldier had undergone eleven operations with soft tissue and bone removal to achieve secondary wound closure, while the radius fracture was only stabilised with a ring fixator. After six further operations and systemic antibiotic therapy to eradicate the surgical site, a bone reconstruction was performed at the Hannover Medical School using the BellaSeno resorbable scaffold in combination with an autologous bone graft from the medullary canal of the femur. The device is based on Resomer®, a bioresorbable polymer platform from Evonik. The surgery was successful and after three months the patient showed a timely bone integration and adequate function of the elbow with no signs of wound healing disruption. There were also no clinical signs of infection. The case study was published this month in the Journal of Personalised Medicine.
The device was developed by the company BellaSeno (BioCity Leipzig) as a customised mesh that is perfectly adapted to the patient's anatomy and ensures a secure hold of the autologous bone graft (RIA material) in the large cavity. In order to allow proper internal vascularisation through the placement of an arterio-venous loop or central vascular pedicle during reconstructive surgery, certain design features were taken into account to allow the placement of such a fragile structure within the scaffold. The device was manufactured using BellaSeno's AI-driven additive manufacturing equipment.
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