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Cell atlas for liver regeneration
Researchers from Leipzig University Medicine, the Max Planck Institute for Evolutionary Anthropology, TU Dresden and ETH Zurich have analysed 21,000 cells from liver tissue samples in a study and created a cell atlas. The study published in "Nature Communications" shows changes in the cell types of the liver before and after regeneration, examined using portal vein embolisation (PVE).
30/07/2024
Tissue samples from patients after PVE were analysed to understand liver regeneration. Dr Georg Damm emphasises that the cell atlas of the healthy human liver provides insights into diseases such as fibrosis, cirrhosis and liver cancer. The atlas reveals upregulated genes associated with developmental processes, cell adhesion and inflammation, as well as changes in the architecture of the smallest liver structural units.
The researchers also found adaptations in the composition of vascular and immune cells, indicating a dynamic adaptation of liver tissue. The communication between liver cell types shows connective tissue cells as a central switching centre. Prof Dr Daniel Seehofer is hoping for new therapeutic approaches and is planning further studies to validate the mechanisms.
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