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How nutrition can influence the ageing brain

A new study by the Leibniz Institute on Ageing in Jena shows that the protein landscape in the brain changes significantly with age and that targeted nutrition can partially slow down these processes. At the centre of the study is ubiquitylation, a chemical process in which proteins are labelled, which determines whether they remain active or are degraded. The researchers observed that this system becomes unbalanced in the ageing brain and that the cellular recycling system loses efficiency.
20/11/2025

One finding from experiments with older mice is particularly exciting. A short-term change in diet resulted in certain protein markers approaching the patterns of younger animals. This shows that nutrition can still have a measurable effect on central molecular processes even at an advanced age. The results thus provide new starting points for research into neurodegenerative diseases and suggest that the protein balance of the brain not only changes with age, but can also be specifically influenced. This opens a window for future strategies to slow down age-related damage to nerve cells and maintain brain performance for longer.

Press release by "Informationsdienst Wissenschaft e.V." from 20 November 2025

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