Webinar: Current Progress in Vaccine Development Against Klebsiella pneumoniae From Antigen Discovery to Clinical Translation

Klebsiella pneumoniae poses a growing global threat due to rising multidrug resistance and hypervirulence. This talk reviews current vaccine approaches—including glycoconjugates, protein antigens, and OMVs—alongside key translation challenges like antigenic diversity and preclinical models.

Highlights of the presentation

• The clinical and public-health importance of multidrug-resistant and hypervirulent K. pneumoniae.
• Current understanding of protective immunity against colonisation, invasive infection, pneumonia, and sepsis.
• Capsular polysaccharides and lipopolysaccharide O antigens as vaccine targets.
• Progress in glycoconjugate, recombinant protein, outer-membrane-vesicle, and multivalent vaccine platforms.
• Use of reverse vaccinology, structural biology, and computational antigen-selection approaches.
• Challenges created by capsular and serotypic diversity.
• Selection of clinically relevant animal models, endpoints, and target populations.
• Key scientific and translational requirements for advancing candidates towards clinical development.
• Future opportunities for integrating vaccination with antimicrobial-resistance control strategies.

More information